Do Tea Polyphenols Affect the Liver?
Introduction
Green and black the products, in particular, are praised for their potential health benefits, which include antioxidant properties and support for weight loss. On the other hand, people are more interested in and concerned about the liver's health. We will go over the advantages, disadvantages, and safety concerns of natural tea polyphenols in detail in this blog.
What Are Tea Polyphenols and Their Benefits?
The products are naturally occurring compounds like the catechins found in green tea and the theaflavins and thearubigins found in black tea. These substances are well-known for their antioxidant and anti-inflammatory properties.
Benefits of tea polyphenols for health
Highlighted Antioxidants: The products reduce oxidative stress and prevent cell damage by scavenging free radicals.
Studies: Research distributed in "Sub-atomic Sustenance and Food Exploration" features that catechins, especially epigallocatechin gallate (EGCG), are powerful cancer prevention agents that assist with safeguarding cells from oxidative harm.
Effects on inflammation: Polyphenols adjust incendiary pathways, possibly lessening the gamble of ongoing sicknesses.
Mechanism: The products can reduce inflammation by inhibiting cytokines that promote inflammation.
Health of the Heart: Normal utilization of tea has been connected to further developed heart wellbeing, including decreased circulatory strain and cholesterol levels.
Studies: A meta-examination in "The American Diary of Clinical Nourishment" observed that green tea utilization is related with lower LDL cholesterol and circulatory strain levels.
Cancer Avoidance: According to some studies, tea polyphenols may prevent some types of cancer by preventing the growth of cancer cells and triggering apoptosis.
Research: In the "Journal of Nutrition," research showed that EGCG can slow the growth of tumors in various cancer models.
The liver benefits of tea polyphenols
By forestalling oxidative pressure, decreasing fat gathering, and bringing down the gamble of liver illnesses, the products have shown guarantee in advancing liver wellbeing.
Liver Infections: It was discovered that EGCG reduced liver fat and improved liver function in patients with non-alcoholic fatty liver disease (NAFLD).
Studies: According to a study that was published in "The Journal of Hepatology," EGCG supplementation significantly reduced liver fat and improved liver enzyme levels in patients with NAFLD.
Liver Protection: The products have cancer prevention agent properties that assist with safeguarding liver cells from harm welcomed on by poisons and oxidative pressure.
Mechanism: The products can lessen liver damage by neutralizing free radicals and strengthening the body's antioxidant defenses.
Can Tea Polyphenols Cause Liver Damage?
High portions of the products, particularly when taken as enhancements, have been connected to liver harmfulness in certain occasions, in spite of their various possible advantages.
Risks of High-Dose Supplements
Violent Liver Disease: Certain individuals' liver harm has been connected to high portions of tea polyphenol supplements, especially green tea removes.
Studies: Green tea extract supplementation was linked to liver damage, according to "Liver International" research. Jaundice, liver inflammation, and elevated liver enzymes were some of the symptoms.
Case Studies: High-dose green tea extracts have been linked to acute liver damage in a number of case studies.
Evidence: As per a survey that was distributed in "Hepatology," supplements containing green tea remove have been connected to various instances of liver harm, some of which required hospitalization.
The Component of Liver Poisonousness
High dosages of natural tea polyphenols may cause liver harm through oxidative pressure, mitochondrial harm, and resistant interceded liver harm, yet the specific component is obscure.
Oxygen Shock: In spite of their cell reinforcement properties, polyphenols can oddly create receptive oxygen species (ROS) in huge amounts, bringing about oxidative pressure.
Studies: Over the top EGCG might harm liver cells and cause oxidative pressure, as per research distributed in "Toxicology and Applied Pharmacology."
Dietary deterioration: Because it can affect how mitochondria work, EGCG can harm the liver and kill cells if it is present in high concentrations.
Mechanism: An excessive amount of EGCG can damage hepatocytes by disrupting the membranes of mitochondria and the production of ATP.
Immune Reaction: The liver may become inflamed as a result of an immune-mediated response to high-dose the products in some people.
Evidence: High-dose consumption of green tea extract has been linked to immune-mediated liver damage, according to studies published in "Clinical Gastroenterology and Hepatology."
Guidelines for Safe Consumption
To limit the gamble of liver harm, observing safe utilization guidelines is significant:
Moderation: Tea is generally safe and has been linked to health benefits when consumed in moderation, such as three to four cups per day.
Recommendations: The European Food Safety Authority (EFSA) recommends consuming up to 800 mg of EGCG daily from tea infusions without concern for liver toxicity.
Keep away from High-Portion Enhancements: High-portion green tea separate enhancements ought to be utilized with watchfulness, and people ought to counsel medical services suppliers prior to beginning any new enhancement routine.
Advice: Supplements that exceed the recommended daily intake of the products should be avoided.
Capacity for Liver Screening: Users of high-dose green tea extract should monitor their liver function and look for liver damage symptoms like fatigue, jaundice, and abdominal pain.
Are Certain Individuals More at Risk?
Certain people might be more defenseless to liver harm from tea polyphenols, especially those with prior liver circumstances, hereditary inclinations, or those taking specific prescriptions.
Previous Liver Circumstances
High-dose the products may be more harmful to the liver in people with liver conditions like hepatitis, cirrhosis, or fatty liver.
Studies: According to a study published in the "World Journal of Gastroenterology," high-dose green tea extracts have the potential to exacerbate liver damage, so individuals who already suffer from liver conditions should exercise caution when taking them.
Predispositional Signs
Genetic factors can influence an individual's susceptibility to liver damage caused by the products.
Evidence: Differences in the genes responsible for polyphenol metabolism, like the cytochrome P450 enzymes, can affect how the polyphenols in tea are metabolized and how they react to their environment.
Medication Interactions
The products can connect with explicit drugs, conceivably extending the bet of liver injury.
Mechanism: The products can alter the pharmacokinetics of medications, increasing liver burden and toxicity by inhibiting or inducing drug-metabolizing enzymes.
Examples: The liver-metabolized statins, warfarin, and some antidepressants may interact with the products.
Conclusion
When consumed in moderation as part of a diet that is well-balanced, natural tea polyphenols have numerous health benefits, particularly for the liver. In any case, high portions, particularly from supplements, can present dangers of liver poisonousness. It is critical to observe safe utilization rules, know about individual gamble factors, and counsel medical care suppliers while considering high-portion tea polyphenol supplements.
References
1. Lambert, J. D., Sang, S., Yang, C. S. "Possible Controversy of Exogenous Green Tea Polyphenols on Iron Absorption." Journal of Agricultural and Food Chemistry.
2. Mazzanti, G., Di Sotto, A., Vitalone, A. "Green tea polyphenols and human health: An update." Current Opinion in Clinical Nutrition and Metabolic Care.
3. McKay, D. L., Blumberg, J. B. "The role of tea in human health: An update." Journal of the American College of Nutrition.
4. Nagao, T., Hase, T., Tokimitsu, I. "A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans." Obesity Research.
5. Seeram, N. P. "Epigallocatechin gallate-induced Toxicity in Hepatocytes." Regulatory Toxicology and Pharmacology.
6. Wang, H., Provan, G. J., Helliwell, K. "Tea flavonoids: their functions, utilization and analysis." Trends in Food Science & Technology.
7. Chow, H. H., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., ... & Alberts, D. S. (2006). Effects of dose and ingestion time on the oral bioavailability of green tea polyphenols in humans. Cancer Epidemiology Biomarkers & Prevention, 15(4), 856-861.
